BDBM50462326 CHEMBL4251024

SMILES CC(C)Cc1ccc(cc1)C(C)c1nc2cc(CCC(O)=O)ccc2n1Cc1ccccc1Cl

InChI Key InChIKey=SIFBQIMEQWYVBG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50462326   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462326(CHEMBL4251024)
Affinity DataIC50: 70nMAssay Description:Inhibition of FLAP in A23187-stimulated human monocytes assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462326(CHEMBL4251024)
Affinity DataIC50: 50nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462326(CHEMBL4251024)
Affinity DataIC50: 60nMAssay Description:Inhibition of 5-LO in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLeukotriene C4 synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462326(CHEMBL4251024)
Affinity DataIC50: 30nMAssay Description:Inhibition of LTC4 synthase in LPS/fMLP-stimulated human monocytes assessed as decrease in cys-LT formation pre-incubated with LPS for 30 mins and la...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed