BDBM50461683 CHEMBL4227184

SMILES Brc1ccccc1C(=O)Nc1cccc(NC(=O)CCC#C)c1

InChI Key InChIKey=DTNVSQNZXJPVMA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50461683   

TargetProteinase-activated receptor 1(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50461683(CHEMBL4227184)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50461683(CHEMBL4227184)
Affinity DataIC50: 9.99E+4nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50461683(CHEMBL4227184)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of PAR1 in human EAhy926 cells assessed as reduction in TFLLRN-NH2-induced intracellular calcium mobilization incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed