BDBM50461175 CHEMBL4225565

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n([C@H]4CC[C@H](O)CC4)c3n2)cc1

InChI Key InChIKey=GACHVPHWYJEGML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50461175   

TargetEpidermal growth factor receptor(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50461175(CHEMBL4225565)
Affinity DataIC50: 529nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50461175(CHEMBL4225565)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed