BDBM50461084 CHEMBL4225088

SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(CO)c1

InChI Key InChIKey=LZLBRISQTJVZNP-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50461084   

TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 20nMAssay Description:Activity at APC-labeled 6His-tagged human RORgamma LBD (263 to 518 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 3.20nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as reduction in Th17 level incubated for 5 days by MSD electrochemilumin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 10nMAssay Description:Displacement of BODIPY from APC-labelled RORgammat LBD (unknown origin) incubated for 1 hrs by binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at RORgammat (unknown origin) transfected in human Jurkat cells assessed as inhibition of RORgammat transcriptional activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgammat (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 1.70nMAssay Description:Inverse agonist activity at GST-tagged RORgammaT LBD (unknown origin) expressed in insect cells assessed as inhibition of biotinyl-NH-Ahx NSHQKVTLLQL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 10nMAssay Description:Displacement of BODIPY from APC-labelled human RORgammat LBD incubated for 15 mins by by LANCE detection analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50: 30nMAssay Description:Inhibition of RORgammat in human Jurkat cells assessed as inhibition of RORgammat transcriptional activity incubated for 10 mins by luciferase report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed