BDBM50460939 CHEMBL4228654

SMILES CC(C)Nc1ccc2cnn(-c3cncc(n3)-c3ccc(cc3)C(O)=O)c2c1

InChI Key InChIKey=RJXWGPDMMDILGJ-UHFFFAOYSA-N

Data  15 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50460939   

LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 54nMAssay Description:Inhibition of DYRK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 120nMAssay Description:Inhibition of human PIM1More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 3nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 260nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human PIM2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 110nMAssay Description:Inhibition of CK2alpha in human HCT116 or human DLD1 cells assessed as decrease in AKT phosphorylation at S129 residue after 3 to 24 hrs by Western b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 7nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 360nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 3nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed