BDBM50460600 CHEMBL118266::US20240190828, Compound 6d

SMILES c1sc(nc1-c1cccnc1)-c1cccnc1

InChI Key InChIKey=ITJUUTBLPGKSOG-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50460600   

TargetAromatase(Human)
Istanbul Medipol University

Curated by ChEMBL
LigandPNGBDBM50460600(CHEMBL118266 | US20240190828, Compound 6d)
Affinity DataIC50: 4nMAssay Description:Inhibition of aromatase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50460600(CHEMBL118266 | US20240190828, Compound 6d)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of N-terminal GST-tagged MNK1 (unknown origin) (37 to 341 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50460600(CHEMBL118266 | US20240190828, Compound 6d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 (unknown origin) (72 to 385 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50460600(CHEMBL118266 | US20240190828, Compound 6d)
Affinity DataIC50: 3.05E+5nMAssay Description:Inhibition of Axl (unknown origin) using 5'FAM labeled KKKKEEIYFFF-NH2 peptide as substrate incubated for 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
Medical College of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50460600(CHEMBL118266 | US20240190828, Compound 6d)
Affinity DataKd:  1.39E+6nMAssay Description:Binding affinity to 15N-labeled recombinant human PBRM1 BD2 transfected in Escherichia coli BL21 (DE3) assessed as 1H/13N chemical shift perturbation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProtein polybromo-1 [200-270](Human)
The Medical College of Wisconsin, Inc.

US Patent
LigandPNGBDBM50460600(CHEMBL118266 | US20240190828, Compound 6d)
Affinity DataKd:  1.39E+6nMAssay Description:No detail is given.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent