BDBM50460387 CHEMBL4227281

SMILES Cc1ccc(\C=N\NC(=O)N2CCc3ncnc(Nc4cccc(c4)C(F)(F)F)c3C2)cc1

InChI Key InChIKey=NLAXMHQWTOCNAO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50460387   

TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50460387(CHEMBL4227281)
Affinity DataIC50: 152nMAssay Description:Inhibition of VEGFR2 (unknown origin) using peptide substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50460387(CHEMBL4227281)
Affinity DataIC50: 3.22E+3nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using peptide substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50460387(CHEMBL4227281)
Affinity DataIC50: 24nMAssay Description:Inhibition of EGFR (unknown origin) using peptide substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50460387(CHEMBL4227281)
Affinity DataIC50: 29nMAssay Description:Inhibition of glycosylated human ATX using FS-3 as substrate preincubated for 45 mins under shaking condition followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed