BDBM50459845 CHEMBL4227437

SMILES COCCn1cc(COc2cccc(Cc3cnc(NC(=O)CSc4nc(C)cc(C)n4)s3)c2)nn1

InChI Key InChIKey=MAUGCLAAQLDMTD-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50459845   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged Sirt1 (133 to 747 residues) using Z-(Ac)Lys-AMC as substrate measured after 4 hrs by high-throughput fluor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human His10-tagged Sirt3 (118 to 395 residues) expressed in Escherichia coli BL21(DE3) using Z-(Ac)Lys-AMC as substrate mea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human His10-tagged Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21(DE3) using Z-(Ac)Lys-AMC as substrate meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 118nMAssay Description:Inhibition of N-terminal His6-tagged human Sirt2 (25 to 389 residues) using ZMAL as substrate incubated for 4 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human Sirt1 (134 to 747 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate at incubated for 4 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human Sirt3 (118 to 395 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) mediated demyristoylation activity using ZMM...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 120nMAssay Description:Inhibition of N-terminal 6His-tagged human Sirt2 (25 to 389 residues) expressed in Escherichia coli BL21(DE3) using ZMAL as substrate incubated for 4...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)