BDBM50459842 CHEMBL4228286

SMILES Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(Cc5ccccc5)nn4)c3)s2)n1

InChI Key InChIKey=YWLNYZXFIAFWSF-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50459842   

TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human His10-tagged Sirt3 (118 to 395 residues) expressed in Escherichia coli BL21(DE3) using Z-(Ac)Lys-AMC as substrate mea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human His10-tagged Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21(DE3) using Z-(Ac)Lys-AMC as substrate meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged Sirt1 (133 to 747 residues) using Z-(Ac)Lys-AMC as substrate measured after 4 hrs by high-throughput fluor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His-tagged human recombinant HDAC3 (1 to 428 residues)/N-terminal GST tagged human NcoR2 (395 to 489 residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) mediated demyristoylation activity using ZMM...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 200nMAssay Description:Inhibition of Sireal-TAMRA tracer binding to Sirt2 in HEK293 cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 160nMAssay Description:Inhibition of N-terminal 6His-tagged human Sirt2 (25 to 389 residues) expressed in Escherichia coli BL21(DE3) using ZMAL as substrate incubated for 4...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)