BDBM50459778 Ascofuranone::US11565996, Compound Ascochlorin
SMILES [H][C@]1(CC(=O)C(C)(C)O1)C(\C)=C\CC\C(C)=C\Cc1c(O)c(Cl)c(C)c(C=O)c1O
InChI Key InChIKey=VGYPZLGWVQQOST-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50459778
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant DHODH expressed in Escherichia coli BL21(DE3) cells by microplate reader analysisMore data for this Ligand-Target Pair
TargetAlternative oxidase, mitochondrial(Trypanosoma brucei brucei)
Instituto De Qu£Mica M£Dica
Curated by ChEMBL
Instituto De Qu£Mica M£Dica
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant Trypanosoma brucei brucei alternative oxidase using ubiquinol-1 as substrate incubated for 2 mins followed by substrate add...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of recombinant N-terminal His-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli using DL-dihydroorotic acid as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 187nMAssay Description:Table 1 summarises the concentration of inhibitor required to reduce the respiration of purified recombinant AOX protein by 50%. Respiration was meas...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Table 1 summarises the concentration of inhibitor required to reduce the respiration of purified recombinant AOX protein by 50%. Respiration was meas...More data for this Ligand-Target Pair
TargetAlternative oxidase, mitochondrial(Trypanosoma brucei brucei)
Instituto De Qu£Mica M£Dica
Curated by ChEMBL
Instituto De Qu£Mica M£Dica
Curated by ChEMBL
Affinity DataKi: 0.130nMAssay Description:Inhibition of Trypanosoma brucei alternative oxidase expressed in Escherichia coli FN102 using ubiquinol-1 as substrate preincubated for 2 mins follo...More data for this Ligand-Target Pair