BDBM50459033 CHEMBL4211080::US10611730, Example 36

SMILES Cc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1

InChI Key InChIKey=HXOISDVBEMOPLN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50459033   

TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50459033(CHEMBL4211080 | US10611730, Example 36)
Affinity DataIC50: 50nMAssay Description:Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50459033(CHEMBL4211080 | US10611730, Example 36)
Affinity DataIC50: 1.00E+4nMAssay Description:Modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50459033(CHEMBL4211080 | US10611730, Example 36)
Affinity DataIC50: 63.1nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In DepthDetails
US Patent