BDBM50459021 CHEMBL4212408::US10611730, Example 76

SMILES FC(F)(F)Oc1cccc(Cl)c1-c1ccc2[nH]c(=O)sc2c1

InChI Key InChIKey=FFERWAZVBAHCCT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459021   

TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50459021(CHEMBL4212408 | US10611730, Example 76)
Affinity DataIC50: 2.5nMAssay Description:Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50459021(CHEMBL4212408 | US10611730, Example 76)
Affinity DataIC50: 2.51nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In DepthDetails
US Patent