BDBM50457817 CHEMBL4214032

SMILES COc1cc(nc(n1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O

InChI Key InChIKey=YDCFGVAUALAUGQ-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457817   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Genentech

Curated by ChEMBL

LigandBDBM50457817(CHEMBL4214032)Copy SMILESCopy InChI

Affinity DataIC50: 69nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Genentech

Curated by ChEMBL

LigandBDBM50457817(CHEMBL4214032)Copy SMILESCopy InChI

Affinity DataKi:  0.590nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL