BDBM50457815 CHEMBL4211840

SMILES COc1cc(nc(c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O

InChI Key InChIKey=LQSHXYHWYGKAMX-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50457815   

LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50: 34nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of TNFalpha-induced nuclear translocation of NFkB RelA in human HeLa cells preincubated for 4.5 hrs followed by TNFalpha stimulation for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50: 70nMAssay Description:Inhibition of NIK in human HeLa cells assessed as inhibition of non-classical NFkB signaling by measuring reduction in nuclear translocation of p52 p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50: 10nMAssay Description:Inhibition of His6-tagged human NIK (330 to 680 residues) S549D mutant expressed in baculovirus-infected Sf9 cells incubated for 30 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataIC50: 220nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataKi:  66nMAssay Description:Inhibition of PKD1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed