BDBM50457813 CHEMBL4210066

SMILES CCOc1ccn2c(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O

InChI Key InChIKey=LGGMBZNLDBVEEK-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457813   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Genentech

Curated by ChEMBL

LigandBDBM50457813(CHEMBL4210066)Copy SMILESCopy InChI

Affinity DataIC50: 380nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase 14(Human)
Genentech

Curated by ChEMBL

LigandBDBM50457813(CHEMBL4210066)Copy SMILESCopy InChI

Affinity DataKi:  5.90nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL