BDBM50456444 CHEMBL3734823

SMILES CC1=NN(C(=O)\C1=C\c1ccc(o1)-c1cc(C)c(C)cc1[N+]([O-])=O)c1ccc(cc1)C(O)=O

InChI Key InChIKey=HEKJYZZSCQBJGB-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50456444   

TargetHistone acetyltransferase p300(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of p300 (unknown origin) using H3 peptide and acetyl-coA as substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of P300 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataIC50: 6.31E+5nMAssay Description:Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A lev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant Histone acetyltransferase p300 catalytic domain (1284-1672 residues) using [3H]Acetyl-CoA and histone H3 substrate at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of P300 BHC domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of CBP BHC domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataIC50: 1.60E+3nMAssay Description:Noncompetitive inhibition of P300 (1287 to 1652 residues) VMA intein chitin binding domain (unknown origin) expressed in Escherichia coli BL21(RIL)-D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of P300 (unknown origin) (1287 to 1652 residues) expressed in Escherichia coli BL21(RIL)-DE3 cells using [12C]-acetyl-CoA/[14C]-acetyl-CoA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50456444(CHEMBL3734823)
Affinity DataKi:  400nMAssay Description:Inhibition of VMA intein chitin binding domain-fused p300 HAT domain (1287 to 1652 residues) (unknown origin) expressed in Escherichia coli BL21(RIL)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed