BDBM50455992 CHEBI:3687::Chrysophanol

SMILES Cc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI Key InChIKey=LQGUBLBATBMXHT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50455992   

TargetNeutrophil elastase(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50455992(CHEBI:3687 | Chrysophanol)
Affinity DataIC50: 1.80E+4nMAssay Description:Compound was tested for the enzyme inhibitory activity against Human Leukocyte Elastase (HLE) at 28 uM concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50455992(CHEBI:3687 | Chrysophanol)
Affinity DataIC50: 4.62E+4nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 10 mins before substrate addition measured after 5 mins by EIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50455992(CHEBI:3687 | Chrysophanol)
Affinity DataIC50: 3.61E+4nMAssay Description:Inhibition of ovine COX2 using arachidonic acid as substrate preincubated for 10 mins before substrate addition measured after 5 mins by EIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50455992(CHEBI:3687 | Chrysophanol)
Affinity DataIC50: 1.94E+5nMAssay Description:Inhibition of rat liver cytosolic TrxR1 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThioredoxin reductase 2, mitochondrial(Rat)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50455992(CHEBI:3687 | Chrysophanol)
Affinity DataIC50: 1.81E+5nMAssay Description:Inhibition of rat liver mitochondrial TrxR2 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50455992(CHEBI:3687 | Chrysophanol)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed