BDBM50455560 CHEMBL4216093

SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1cccc(O)c1

InChI Key InChIKey=NTKMBZXHYFBSOK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50455560   

TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455560(CHEMBL4216093)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455560(CHEMBL4216093)
Affinity DataIC50: 742nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455560(CHEMBL4216093)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455560(CHEMBL4216093)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455560(CHEMBL4216093)
Affinity DataIC50: 740nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed