BDBM50453823 CHEMBL4208519::US10556883, Compound 19d

SMILES CC(C)CC(=O)N1CC(C1)(N(C)S(=O)(=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO

InChI Key InChIKey=LZUHYMGQNXWOHQ-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50453823   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells assessed as reduction in tail current amplitude by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 4.63E+3nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 7.20nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of recombinant human MMP1 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 20nMAssay Description:Inhibition of TACE in NHEK assessed as reduction in LPS/TPA-stimulated TNFalpha production preincubated for 1 hr followed by LPS/TPA stimulation for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 480nMAssay Description:Inhibition of ADAM9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of MMP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMatrilysin(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 210nMAssay Description:Inhibition of MMP7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 6nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 90nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of ADAM10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 33nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human TACE catalytic domain using Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate after 2 hrs by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed