BDBM50453053 CHEMBL4213802

SMILES CC(C(=O)N[C@H]1CC(=O)OC1O)n1c(=O)c(NC(=O)c2ccc(Nc3cnc4ccccc4n3)cc2)cn(C)c1=O

InChI Key InChIKey=VOVIDOXRASTPAZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50453053   

TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)
Affinity DataIC50: 48nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCaspase-1(Human)
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at 20 times Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed