BDBM50453034 CHEMBL4211859
SMILES CC(C)n1cc(NC(=O)c2ccc(Nc3ccc4ccccc4c3)cc2C)c(=O)n(c1=O)C1(CC1)C(=O)N[C@H]1CC(=O)OC1O
InChI Key InChIKey=BTGMTHBOODBMHN-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50453034
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-3 using Ac-DEVD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-6 using Ac-VEID-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of human recombinant caspase-5 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-8 using Ac-IETD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of caspase-1 in human monocyte-derived macrophages assessed as decrease in LPS-induced IL-1beta secretion after 24 hrs by sandwich immunoa...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase-7 using Ac-DEVD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair