BDBM50451737 CHEMBL4206416

SMILES Clc1ccc(NC(=O)Nc2cccc(Nc3cccc(n3)N3CCCC3)c2)cc1

InChI Key InChIKey=PRWIWVOUYIOPPX-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50451737   

TargetCannabinoid receptor 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50451737(CHEMBL4206416)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of human CB1 receptor expressed in CHO-K1 cell membranes assessed as induction of [3H]CP55,940 binding after 1.5 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMonoglyceride lipase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50451737(CHEMBL4206416)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAGL in human U937 cell homogenate assessed as decrease in [ethanolamine-1-3H]AEA levels preincubated for 30 mins followed by AEA addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50451737(CHEMBL4206416)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAAH in human U937 cell homogenate assessed as decrease in [ethanolamine-1-3H]AEA levels preincubated for 30 mins followed by AEA addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50451737(CHEMBL4206416)
Affinity DataIC50: 180nMAssay Description:Negative allosteric modulation of human CB1 receptor expressed in HEK293 cells assessed as inhibition of 33 nM CP55,940-induced SRE transcriptional a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50451737(CHEMBL4206416)
Affinity DataKi:  5.26E+4nMAssay Description:Displacement of [3H]CP55,940 from human CB2 receptor expressed in CHO-K1 cell membranes after 1.5 hrs by liquid scintillation counting assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed