BDBM50451287 CHEMBL4204596

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2ccccc2N=C=S)n1)N1CCN(C)CC1

InChI Key InChIKey=BBQBCOLDUARXMG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50451287   

TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451287(CHEMBL4204596)
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of EGFR in human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451287(CHEMBL4204596)
Affinity DataIC50: 5.56E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451287(CHEMBL4204596)
Affinity DataIC50: 8.99E+3nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451287(CHEMBL4204596)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451287(CHEMBL4204596)
Affinity DataIC50: 3.07E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed