BDBM50451282 CHEMBL4217686

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2ccc(NC(=O)CCO)cc2)n1)N1CCN(C)CC1

InChI Key InChIKey=LJXQTJZJOXBJJP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50451282   

TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451282(CHEMBL4217686)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451282(CHEMBL4217686)
Affinity DataIC50: 2.33E+4nMAssay Description:Inhibition of EGFR in human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451282(CHEMBL4217686)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Mouse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451282(CHEMBL4217686)
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50451282(CHEMBL4217686)
Affinity DataIC50: 6.12E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed