BDBM50449039 CHEMBL3126209::US9212144, 14 (Ex. 16)

SMILES Nc1ccc2ccc(CCNCCc3ccc(F)cc3)cc2n1

InChI Key InChIKey=DYXOKDDYGCCWSA-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50449039   

TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50449039(CHEMBL3126209 | US9212144, 14 (Ex. 16))
Affinity DataKi:  183nMpH: 7.4Assay Description:To test for enzyme inhibition, the hemoglobin capture assay was used to measure nitric oxide production. The assay was performed at 37° C. in HEPES b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent
LigandPNGBDBM50449039(CHEMBL3126209 | US9212144, 14 (Ex. 16))
Affinity DataKi:  183nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as NO production by hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Bovine)
Northwestern University

US Patent
LigandPNGBDBM50449039(CHEMBL3126209 | US9212144, 14 (Ex. 16))
Affinity DataKi:  8.86E+3nMpH: 7.4Assay Description:To test for enzyme inhibition, the hemoglobin capture assay was used to measure nitric oxide production. The assay was performed at 37° C. in HEPES b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
Go to US Patent

TargetNitric oxide synthase, endothelial(Bovine)
Northwestern University

US Patent
LigandPNGBDBM50449039(CHEMBL3126209 | US9212144, 14 (Ex. 16))
Affinity DataKi:  8.86E+3nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli using L-arginine as substrate assessed as NO production by hemoglobin capture ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Northwestern University

US Patent
LigandPNGBDBM50449039(CHEMBL3126209 | US9212144, 14 (Ex. 16))
Affinity DataKi:  5.12E+4nMpH: 7.4Assay Description:To test for enzyme inhibition, the hemoglobin capture assay was used to measure nitric oxide production. The assay was performed at 37° C. in HEPES b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Mouse)
Northwestern University

US Patent
LigandPNGBDBM50449039(CHEMBL3126209 | US9212144, 14 (Ex. 16))
Affinity DataKi:  5.12E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli using L-arginine as substrate assessed as NO production by hemoglobin capture assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed