BDBM50445349 CHEMBL3104261::US9676701, 63 Enantiomers of 4′-((trans)-2-aminocyclopropyl)biphenyl-3-ol hydrochloride

SMILES N[C@@H]1C[C@H]1c1ccc(cc1)-c1cccc(O)c1

InChI Key InChIKey=DSOJSZXQRJGBCW-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50445349   

TargetLysine-specific histone demethylase 1A(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataIC50: 4.05E+4nMAssay Description:Inhibition of human recombinant LSD1 by horseradish peroxidase-coupled fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataKi:  50nM ΔG°:  -9.95kcal/molepH: 7.4 T: 2°CAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataKi:  50nM ΔG°:  -9.95kcal/molepH: 7.4 T: 2°CAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Oryzon Genomics

US Patent
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataKi: >1.00E+3nMpH: 7.5Assay Description:Assays were conducted in 96-well black plates with clear bottom (Corning) in a final volume of 100 μL. The assay buffer was 100 mM HEPES, pH 7.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Oryzon Genomics

US Patent
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataKi: >1.00E+3nMpH: 7.5Assay Description:Assays were conducted in 96-well black plates with clear bottom (Corning) in a final volume of 100 μL. The assay buffer was 100 mM HEPES, pH 7.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Oryzon Genomics

US Patent
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataKi: >1.00E+3nMpH: 7.5Assay Description:Assays were conducted in 96-well black plates with clear bottom (Corning) in a final volume of 100 μL. The assay buffer was 100 mM HEPES, pH 7.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Oryzon Genomics

US Patent
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataKi: >1.00E+3nMpH: 7.5Assay Description:Assays were conducted in 96-well black plates with clear bottom (Corning) in a final volume of 100 μL. The assay buffer was 100 mM HEPES, pH 7.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent