BDBM50444583 CHEMBL3099716::US9340549, 74

SMILES CC1(C)OC(=O)N([C@H]1c1ccccc1)[C@H]1CC[C@@H](CC1)c1cnc(N)c(c1)-c1ncccn1

InChI Key InChIKey=QTAONPFQLNZKSD-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50444583   

LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 8.30nMT: 2°CAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 1.47nMT: 2°CAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 4.85E+4nMAssay Description:Binding affinity to NK1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 4.85E+4nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 4.85E+4nMAssay Description:Binding affinity to dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 4.85E+4nMAssay Description:Binding affinity to CCR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 2nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50444583(CHEMBL3099716 | US9340549, 74)
Affinity DataIC50: 22nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed