BDBM50444553 CHEMBL3099686

SMILES COC(=O)[C@@]1(CCc2cncn12)c1ccc(cc1Cl)C#N

InChI Key InChIKey=OYOXKESECMPXNQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50444553   

TargetAromatase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50444553(CHEMBL3099686)
Affinity DataIC50: 50nMAssay Description:Inhibition of human CYP19 preincubated for 10 mins followed by protein addition measured after 90 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50444553(CHEMBL3099686)
Affinity DataIC50: 17nMAssay Description:Inhibition of CYP11B2 in human NCI-H295R cells assessed as inhibition of angiotensin-2-induced aldosterone production after 24 hrs by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed