BDBM50442139 CHEMBL2441273

SMILES CCc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1

InChI Key InChIKey=DPRNXTSMYVCYLJ-UHFFFAOYSA-N

Data  2 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50442139   

TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 398nMAssay Description:Inhibition of Aurora-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 398nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 316nMAssay Description:Inhibition of Btk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 251nMAssay Description:Inhibition of Tec (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 200nMAssay Description:Inhibition of CAMKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 158nMAssay Description:Inhibition of IR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 158nMAssay Description:Inhibition of Bmx (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 79nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataIC50: 4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataKi:  0.631nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataKi:  398nMAssay Description:Inhibition of Aurora-B (unknown origin) using 5FAM-PKAtide as substrate after 120 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed