BDBM50441567 CHEMBL2436978::US10485800, Example 181
SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
InChI Key InChIKey=QKKIWEILHCXECO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50441567
Affinity DataIC50: 460nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.05E+3nMAssay Description:Inhibition of wild type human ZAP70 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.29E+3nMAssay Description:Inhibition of wild type human ERK2 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of diclofenac metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of midazolam metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of FLT3-L-stimulated wild type full length human FLT3 autophosphorylation expressed in MEF preincubated for 90 mins followed by FLT3-L sti...More data for this Ligand-Target Pair
Affinity DataIC50: 591nMAssay Description:Inhibition of wild type human IKKa by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 661nMAssay Description:Inhibition of wild type human MEKK2 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 731nMAssay Description:Inhibition of wild type human SYK by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of wild type human ROCK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of wild type human CDK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of MLK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 70nMAssay Description:Binding affinity to human wild type DLK by qPCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 307nMAssay Description:Inhibition of wild type human IGF1R by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human FLT3 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Inhibition of wild type human ABL1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inhibition of wild type human TRKA by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 108nMAssay Description:Inhibition of wild type human Aurora kinase A by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 111nMAssay Description:Inhibition of wild type human ROCK2 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 123nMAssay Description:Inhibition of wild type human Aurora kinase B by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of human wild type DLK by qPCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 177nMAssay Description:Inhibition of wild type human c-MET by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of wild type human IR by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 201nMAssay Description:Inhibition of wild type human SGK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 217nMAssay Description:Inhibition of wild type human TRKB by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 257nMAssay Description:Inhibition of wild type human IKKb by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of wild type human Aurora kinase C kinase by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair