BDBM504402 US11040984, Compound 2

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1N1CC2(CCN(C)CC2)OC1=O

InChI Key InChIKey=PQHBTLFVLADREW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 504402   

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
Medshine Discovery

US Patent
LigandPNGBDBM504402(US11040984, Compound 2)
Affinity DataIC50: 16.5nMAssay Description:Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Medshine Discovery

US Patent
LigandPNGBDBM504402(US11040984, Compound 2)
Affinity DataIC50: 48.1nMAssay Description:Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent