BDBM50439189 CHEMBL2418789::US9126987, 8

SMILES CCSc1nnc(o1)-c1ccc2[nH]cnc2c1

InChI Key InChIKey=QFCSGTKJHJMJDR-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50439189   

TargetGlutaminyl-peptide cyclotransferase(Human)
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50439189(CHEMBL2418789 | US9126987, 8)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Escherichia coli DH5alpha using H-Gln-AMC as substrate by fluorometric analysis in presence of py...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50439189(CHEMBL2418789 | US9126987, 8)
Affinity DataKi:  9.67E+3nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Escherichia coli DH5alpha using H-Gln-AMC as substrate by fluorometric analysis in presence of py...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50439189(CHEMBL2418789 | US9126987, 8)
Affinity DataKi:  9.67E+3nM ΔG°:  -6.95kcal/mole IC50: 1.47E+4nMpH: 8.0 T: 2°CAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30 C. QC activity was evaluated fluorometricall...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2016
Entry Details
Go to US Patent