BDBM50438910 CHEMBL1450796::US9073941, 618

SMILES Cc1ccc(cc1)-c1nn(C)c2nc(=O)n(C)c(=O)c2n1

InChI Key InChIKey=ADLBKNFHIOUYGV-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50438910   

TargetTyrosyl-DNA phosphodiesterase 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)
Affinity DataEC50:  290nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of APE-1 (unknown origin) using double-stranded AP-site containing DNA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrolipoyl dehydrogenase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Academia Sinica

US Patent
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)
Affinity DataIC50: 40nMpH: 7.0Assay Description:The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (2010) 49:1616-1627 and modified for an online robotics sc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Academia Sinica

US Patent
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)
Affinity DataIC50: 40nMpH: 7.0Assay Description:Mtb PDH (Lpd+DlaT+AceE) is provided by Dr. Bryk Ruslana. The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)
Affinity DataIC50: 110nMAssay Description:Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SIRT2 using biotin labeled histone H4 peptide with an acetylated lysine 4 as substrate measured after 1 hr by luminescence analys...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed