BDBM50437147 CHEMBL2403875

SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Nc3ncnc4ccccc34)c2)n(n1)-c1cccc(N)c1

InChI Key InChIKey=VAPRWSMRTJIVDQ-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50437147   

TargetTyrosine-protein kinase ABL1(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437147(CHEMBL2403875)
Affinity DataIC50: 23nMAssay Description:Inhibition of human wild-type ABL (Ser229 to Gln513)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437147(CHEMBL2403875)
Affinity DataIC50: 304nMAssay Description:Inhibition of chicken wild-type cSRC (251 to 533)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437147(CHEMBL2403875)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437147(CHEMBL2403875)
Affinity DataIC50: 235nMAssay Description:Inhibition of DDR1 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437147(CHEMBL2403875)
Affinity DataIC50: 75nMAssay Description:Inhibition of DDR2 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437147(CHEMBL2403875)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by FLiK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed