BDBM50436720 CHEMBL2401963

SMILES CC[C@@H]1C(=O)N(c2cnc(nc2N1C3CCCC3)n4ccnc4c5ccccc5)C

InChI Key InChIKey=JMDRAMDTWLAOHD-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50436720   

TargetSerine/threonine-protein kinase PLK3(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436720(CHEMBL2401963)
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of GST-tagged Plk3 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 15 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436720(CHEMBL2401963)
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50436720(CHEMBL2401963)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)