BDBM50436060 CHEMBL2397100::US10273214, Example 1390

SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1

InChI Key InChIKey=VYMILMYEENZHAR-UHFFFAOYSA-N

Data  2 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50436060   

TargetGlutamate receptor ionotropic, NMDA 1/2D(Rat)
Emory University

Curated by ChEMBL
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Rat)
Emory University

Curated by ChEMBL
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  4.10E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Human)
Emory University

US Patent
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataIC50: 3.00E+3nMAssay Description:The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2D(Human)
Emory University

US Patent
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataIC50: 3.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2D(Human)
Emory University

US Patent
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  2.80E+3nMAssay Description:Positive allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Human)
Emory University

US Patent
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  2.70E+3nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Rat)
Emory University

Curated by ChEMBL
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  5.01E+3nMAssay Description:Positive allosteric modulation of recombinant rat GluN1a/GluN2C receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Rat)
Emory University

Curated by ChEMBL
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  5.01E+3nMAssay Description:Positive allosteric modulation of recombinant rat GluN1a/GluN2D receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed