BDBM50434164 CHEMBL2385272::US9346814, Cmpd No 13 Example 16

SMILES Clc1ccc2c(ccnc2c1)C(=O)NCC(=O)N1CCC[C@H]1C#N

InChI Key InChIKey=NERXNBIHCGOYFQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50434164   

TargetProlyl endopeptidase FAP(Mouse)
Universiteit Antwerp

US Patent
LigandPNGBDBM50434164(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Affinity DataIC50: 7.10nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50434164(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 9(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50434164(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 2(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50434164(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetProlyl endopeptidase(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50434164(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Affinity DataIC50: 1.40E+3nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
Go to US Patent

TargetProlyl endopeptidase(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50434164(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProlyl endopeptidase FAP(Mouse)
Universiteit Antwerp

US Patent
LigandPNGBDBM50434164(CHEMBL2385272 | US9346814, Cmpd No 13 Example 16)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed