BDBM50434072 CHEMBL2381342

SMILES CN(C)Cc1cccc(c1)N=C(C1C(=O)Nc2cc(ccc12)C(=O)N(C)C)c1ccccc1

InChI Key InChIKey=VDNUIDRDCANSTA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50434072   

TargetMitogen-activated protein kinase 7(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 59nMAssay Description:Inhibition of ERK5 phosphorylation in sorbitol-stimulated human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 59nMAssay Description:Inhibition of GST-tagged ERK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-tagged MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MEK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 59nMAssay Description:Inhibition of ERK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 59nMAssay Description:Inhibition of ERK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed