BDBM50433244 CHEMBL2376152

SMILES C[C@@H](NC(=O)c1c[nH]c2ncc(nc12)-c1nn(C)c2cc(Cl)cc(F)c12)C(=O)N1CC(C1)C#N

InChI Key InChIKey=IEMUTVIQLOVPKB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50433244   

TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433244(CHEMBL2376152)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433244(CHEMBL2376152)
Affinity DataIC50: 64nMAssay Description:Inhibition of JAK1 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433244(CHEMBL2376152)
Affinity DataIC50: 56nMAssay Description:Inhibition of JAK2 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433244(CHEMBL2376152)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433244(CHEMBL2376152)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK2 in human monocytes expressing CD14 assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433244(CHEMBL2376152)
Affinity DataIC50: 430nMAssay Description:Inhibition of JAK3/1 in human T cells expressing CD3 assessed as inhibition of IL2-stimulated STAT5a phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed