BDBM50431077 CHEMBL2338787::US10202399, Example 48::US10463663, Example 56::US11129828, Example 56::US9212147, 48::US9290456, 56::US9931340, Example 56

SMILES CC(c1ccccc1)c1cc(O)c(=O)[nH]n1

InChI Key InChIKey=XKZZYQUOKITTMO-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50431077   

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 4.90nMpH: 7.5 T: 2°CAssay Description:The DAAO inhibitory activity was measured by assaying the amount of hydrogen peroxide (H2O2) produced by reacting DAAO protein with flavin adenine di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:This test was performed by partially modifying the method of Philip et. al. (J. Biomol. Screen. Vol. 11, pp 481-487, 2006). HEK293 cells that stably ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 32nMpH: 7.4 T: 2°CAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Rat)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Mouse)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 4.90nMAssay Description:The DAAO inhibitory activity was measured by assaying the amount of hydrogen peroxide (H2O2) produced by reacting DAAO protein with flavin adenine di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 32nMAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2020
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 32nMAssay Description:The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent

TargetD-amino-acid oxidase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50431077(CHEMBL2338787 | US9290456, 56 | US9212147, 48 | US...)
Affinity DataIC50: 32nMAssay Description:Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
Go to US Patent