BDBM50430949 CHEMBL2337399::US9162979, 41-II

SMILES Cc1c(CCOCCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1

InChI Key InChIKey=LGEVLTJETXTQSY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50430949   

TargetProstaglandin G/H synthase 2(Human)
Rottapharm Biotech

US Patent
LigandPNGBDBM50430949(CHEMBL2337399 | US9162979, 41-II)
Affinity DataIC50: 940nMT: 2°CAssay Description:The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin G/H synthase 2(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50430949(CHEMBL2337399 | US9162979, 41-II)
Affinity DataIC50: 940nMAssay Description:Inhibition of Escherichia coli lipopolysaccharide-induced COX2 activity in mouse J774 cells assessed as decrease in PGE2 levels after 24 hrs by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50430949(CHEMBL2337399 | US9162979, 41-II)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of arachidonic acid-induced COX1 activity in mouse J774 cells assessed as decrease in PGE2 levels incubated for 15 mins prior to arachidon...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed