BDBM50430022 CHEMBL2144069

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1

InChI Key InChIKey=ZGBGPEDJXCYQPH-UHFFFAOYSA-N

Data  14 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50430022   

LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 380nMAssay Description:Inhibition of wild type CRAF (unknown origin) using biotinylated MEK as substrate and MgCl2 incubated for 20 mins prior to MgCl2 addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 2.64E+3nMAssay Description:Inhibition of human recombinant N-terminus His-tagged BRAF expressed in Sf9 cells coexpressing CDC37 using biotinylated MEK as substrate and MgCl2 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetHeat shock factor protein 1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 27nMAssay Description:Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 51nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 348nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human GST-tagged BRAF V600E mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPirin(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of 6-amino-9-(2-((4-((2-((6-((5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)carbamoyl)quinolin-2-yl)oxy)ethyl)amino)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 34nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 105nMAssay Description:Inhibition of wild type B-Raf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type B-RAF (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50430022(CHEMBL2144069)
Affinity DataIC50: 1nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)