BDBM50428716 CHEMBL2333128::US9884828, 2-41

SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CC1

InChI Key InChIKey=HAZVCDSGCISCHC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50428716   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428716(CHEMBL2333128 | US9884828, 2-41)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428716(CHEMBL2333128 | US9884828, 2-41)
Affinity DataIC50: 54nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by TR-FRET assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428716(CHEMBL2333128 | US9884828, 2-41)
Affinity DataIC50: 17nMAssay Description:Inhibition of CSF1R (unknown origin) by TR-FRET assay in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428716(CHEMBL2333128 | US9884828, 2-41)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent