BDBM50428708 CHEMBL2333136::US9884828, 1-5

SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(N)c(nnc2c1)C(N)=O

InChI Key InChIKey=LGJDNSHFSUCVIW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50428708   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428708(CHEMBL2333136 | US9884828, 1-5)
Affinity DataIC50: 142nMAssay Description:Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428708(CHEMBL2333136 | US9884828, 1-5)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent