BDBM50428700 CHEMBL2333116::US9884828, 2-53

SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cn[nH]c1)C(N)=O

InChI Key InChIKey=XFTPWNPHPOUHGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50428700   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428700(CHEMBL2333116 | US9884828, 2-53)
Affinity DataIC50: 12nMAssay Description:Inhibition of wild type GST-tagged LRRK2 (970 to 2527 amino acid residues) (unknown origin) assessed as inhibition of biotinylated-LRRKtide phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50428700(CHEMBL2333116 | US9884828, 2-53)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent