BDBM50428271 CHEMBL2337032

SMILES Cc1c(ccc(c1Cl)C(=O)Nc2cc(ccc2N3CCN(CC3)C)N(=O)=O)F

InChI Key InChIKey=QHWMIGPLLWYRIR-UHFFFAOYSA-N

Data  2 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50428271   

TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50428271(CHEMBL2337032)
Affinity DataKd:  380nMAssay Description:Binding affinity to human poly His-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21(DE3)-V2R-pRARE2 cells by surface plasmon resona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50428271(CHEMBL2337032)
Affinity DataIC50: 339nMAssay Description:Inhibition of 10mer-Thr-FAM probe binding to His-tagged human WDR5 expressed in Escherichia coli incubated for 2 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50428271(CHEMBL2337032)
Affinity DataKd:  270nMAssay Description:Displacement of N-terminal isothiocyanate-fluorescein-labeled H3(ARTKQTARKSTGGKA) peptide from human WDR5 expressed in Escherichia coli BL21(DE3) by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50428271(CHEMBL2337032)
Affinity DataIC50: 338nMAssay Description:Inhibition of 10mer-Thr-FAM probe binding to human WDR5 after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)