BDBM50427065 CHEMBL2322875

SMILES COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1nc(c(Cl)c1C)C(F)(F)F

InChI Key InChIKey=PTHJVFQTMJMDKU-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50427065   

TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL23/CKbeta8.1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 6nMAssay Description:Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 1.60E+4nMAssay Description:Binding affinity to human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Mouse)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in mouse WEHI274.1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Mouse)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at CCR1 in mouse WEHI274.1 cells assessed as inhibition of CCL3/MIP-1alpha-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 1.00E+4nMAssay Description:Competitive inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 1.00E+4nMAssay Description:Competitive inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 1.00E+4nMAssay Description:Competitive inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 1.00E+4nMAssay Description:Competitive inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chemocentryx

Curated by ChEMBL
LigandPNGBDBM50427065(CHEMBL2322875)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed