BDBM50425864 CHEMBL2312649

SMILES CN(C)C1CCC(CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1C(=O)NC1CCN(C)CC1

InChI Key InChIKey=SQKBBDOFPPNVCL-UHFFFAOYSA-N

Data  31 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50425864   

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase receptor TYRO3(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetP-selectin(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 400nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase ABL1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 7.61E+3nMAssay Description:Inhibition of ABL (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRAC-alpha serine/threonine-protein kinase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetAurora kinase A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Aurora-A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of BTK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of CAMK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase Chk2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetDual specificity protein kinase CLK1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.45E+3nMAssay Description:Inhibition of CLK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetEphrin type-A receptor 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ECK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetFibroblast growth factor receptor 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GSK3-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKK-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetInsulin receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of INSR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase Lck(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 610nMAssay Description:Inhibition of LCK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetMitogen-activated protein kinase kinase kinase 9(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of MAP3K9 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 120nMAssay Description:Inhibition of MAP4K4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetMitogen-activated protein kinase 1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase MARK1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MARK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase 26(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MASK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase 3(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MST2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 8.27E+3nMAssay Description:Inhibition of MYLK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase Nek2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NEK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50425864(CHEMBL2312649)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL