BDBM50421673 CHEMBL5283441
SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccnc(Cl)c2)cc1C(F)(F)F
InChI Key InChIKey=UWDRPHXOMMPVSE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50421673
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
William S. Middleton Veterans Hospital
Curated by ChEMBL
William S. Middleton Veterans Hospital
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant PknB (1 to 331 residues) expressed in Escherichia coli BL21-Rosetta cells using GarA and ATP as ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
William S. Middleton Veterans Hospital
Curated by ChEMBL
William S. Middleton Veterans Hospital
Curated by ChEMBL
Affinity DataKd: 48nMAssay Description:Binding affinity to Mycobacterium tuberculosis recombinant N-terminal His-tagged PknB (1 to 331 residues) expressed in Escherichia coli DH5alpha cell...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
William S. Middleton Veterans Hospital
Curated by ChEMBL
William S. Middleton Veterans Hospital
Curated by ChEMBL
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human Cdk2/Cyclin A using Myelin basic protein as substrate by ATP competitive assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
William S. Middleton Veterans Hospital
Curated by ChEMBL
William S. Middleton Veterans Hospital
Curated by ChEMBL
Affinity DataKd: 47nMAssay Description:Binding affinity to Mycobacterium tuberculosis partial length PknB (M1 to G279 residues) expressed in mammalian expression system by KdELECT kinase a...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
William S. Middleton Veterans Hospital
Curated by ChEMBL
William S. Middleton Veterans Hospital
Curated by ChEMBL
Affinity DataKd: 440nMAssay Description:Binding affinity to human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system/CyclinD3 by KdELECT kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.60E+3nMAssay Description:Binding affinity to human full length GSK-3 beta (M1 to T433 residues) expressed in mammalian expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Human)
William S. Middleton Veterans Hospital
Curated by ChEMBL
William S. Middleton Veterans Hospital
Curated by ChEMBL
Affinity DataKd: 690nMAssay Description:Binding affinity to human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Human)
William S. Middleton Veterans Hospital
Curated by ChEMBL
William S. Middleton Veterans Hospital
Curated by ChEMBL
Affinity DataKd: 2.20E+3nMAssay Description:Binding affinity to human partial length Pim1 (A15 to K313 residues ) expressed in bacterial expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
William S. Middleton Veterans Hospital
Curated by ChEMBL
William S. Middleton Veterans Hospital
Curated by ChEMBL
Affinity DataKi: 290nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant PknB (1 to 331 residues) expressed in Escherichia coli BL21-Rosetta cells using GarA and ATP as ...More data for this Ligand-Target Pair