BDBM50421198 CHEMBL2087287

SMILES COc1cc(C(=O)c2cccc(C)c2)c(Oc2c(Br)cc(CC(O)=O)cc2Br)cc1C(C)C

InChI Key InChIKey=TZASJPUDKFUECT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50421198   

TargetGlucocorticoid receptor(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50421198(CHEMBL2087287)
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in baculovirus infected Sf9 cells after overnight incubation by scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50421198(CHEMBL2087287)
Affinity DataIC50: 410nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in GRAF cells assessed as inhibition of dexamethasone-induced alkaline phosphatase exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50421198(CHEMBL2087287)
Affinity DataIC50: 2.49E+3nMAssay Description:Antagonist activity at glucocorticoid receptor in rat hepatocytes assessed as inhibition of dexamethasone-induced trypsine aminotransferase expressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50421198(CHEMBL2087287)
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in baculovirus infected Sf9 cells after 16-18 hrs by beta countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50421198(CHEMBL2087287)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in CHOK1 cells assessed as inhibition of dexamethasone-induced alkaline phosphatase ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Zydus Research Centre

Curated by ChEMBL
LigandPNGBDBM50421198(CHEMBL2087287)
Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at glucocorticoid receptor in rat H4IIE cells assessed as inhibition of dexamethasone-induced trypsine aminotransferase expressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed